IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E173

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Prorenin/renin and insulin resistance
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1 Department of Pharmacology and Life Science Research Center, Kagawa University Medical School, Kagawa, Japan
2 Life Science Research Center, Kagawa University Medical School, Kagawa, Japan
Academic Editor:Fumiaki Suzuki
Front. Biosci. (Elite Ed) 2010, 2(3), 1143–1146; https://doi.org/10.2741/E173
Published: 1 June 2010
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)
Abstract

Recently we showed that fructose feeding in rats induced nonproteolytic activation of prorenin and subsequent angiotensin II production in skeletal muscle. In addition, a pharmacological inhibitor of prorenin/(pro)renin receptor interaction attenuated the development of insulin resistance. However, the inhibitor did not ameliorate the glucose intolerance in transgenic rats overexpressing the human renin gene. This review article summarizes the current knowledge of the effects of the prorenin/(pro)renin receptor system on insulin resistance and its potential as a therapeutic target.

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