IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E171

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Amphiphilic copolymers for liquid bandage application studies
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1 Nanobioengineering/Bioelectronics Lab, Department of Biomedical Engineering, Florida International University, 10555 W. Flagler St., Miami, Florida 33174, USA
2 Rochal Industries LLP, 12719 Cranes Mill, San Antonio, TX 78230, USA
3 Institue of Biomedicine and Bioengineering, University of Science and Technology, Beijing, Beijing 100083, P.R. China
4 Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE 205A, Tampa, Florida 33620, USA
Front. Biosci. (Elite Ed) 2010, 2(3), 1123–1133;
Published: 1 June 2010

This research pertains to a new class of liquid bandage polymers which are promising for assisting advanced wound healing by serving as substrates to promote cell viability and proliferation. Amphiphilic nitrogen-containing polymer poly (3-methacryloyloxypropyltris (trimethylsiloxy)silane-co-N-isopropylacrylamide) (poly (TRIS-co-NIPAM)) was synthesized and investigated with further comparison to several different wound care polymers including commercialized 3M NexcareTM No Sting Liquid Bandage. Cell viability on different polymers was tested on fetal human skin fibroblasts (HSFs) and neonatal human epidermal keratinocytes (HEKs). Test results were quantified by Sulforhodamine B (SRB) in vitro cytotoxicity assay. It is demonstrated that both HSFs and HEKs survive better on the poly (TRIS-co-NIPAM) film as the cell seeding substrate compared to other candidate polymer formulations, as well as to the commercial 3M No Sting Liquid Bandage polymer. Thus we conclude that wound healing could be accelerated by this new class of liquid bandage polymer, particularly for early-stage wounds due to a cell substrating effect.

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