IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E147

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Smad anchor for receptor activation (SARA) in TGF-beta signaling

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1 Kidney institute, Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, China
2 Department of Pathology and Medicine, Northwestern University, Chicago, Illinois, USA
Front. Biosci. (Elite Ed) 2010, 2(3), 857–860; https://doi.org/10.2741/E147
Published: 1 June 2010
Abstract

Smad anchor for receptor activation (SARA) is known as Smad cofactor that interacts directly with Smad2/3 and functions to recruit Smad2/3 to the TGF-beta receptor. SARA plays an essential role in TGF-beta-induced Smad2 activation and it can modulate TGF-beta signaling through verify the balances of Smad2 and Smad3. SARA also functions as an anchor for catalytic subunit of protein phosphatase 1 (PP1c) and maybe involved in the dephosphorylation of TGF-beta type I receptor (TbetaR-I) mediated by Smad7. The expression of SARA changes as the development of epithelial to mesenchymal transition (EMT) and fibrosis and it plays a critical role in the maintenance of epithelial cell phenotype. Modulation of SARA may provide a new therapeutic approach to TGF-beta-mediated EMT and fibrosis.

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