IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E141

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Pentraxin-3 in late-preterm newborns with hypoxic respiratory failure
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1 Department of Pediatrics, Unit of Neonatology and Pediatric Cardiology, University of Catania, Via S. Sofia, 78, 95125 Catania, Italy
2 Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Viale Andrea Doria, 6, 95125, Catania, Italy
3 Department of Cardiac Surgery S. Donato Milanese University Hospital, Via G. Morandi, 30 20097, S. Donato Milanese, Italy
4 Faculty of Medicine, University of Bern, Hochschulstrasse 4 3012, Bern, Swiss
Academic Editor:Giovanni Li Volti
Front. Biosci. (Elite Ed) 2010, 2(3), 805–809; https://doi.org/10.2741/E141
Published: 1 June 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

The aim of this study was: echocardiographical assessment of cardiac alterations in late-preterm newborns with hypoxic respiratory failure (HRF), and, study serum pentraxin-3 (PTX-3) in relation to the severity of respiratory impairment and to some echocardiographic parameters (i.e. ejection fraction (EF), stroke volume (SV) and cardiac output (CO). We enrolled in this study 40 newborn infants whose 22 (group I) with moderate HRF and 18 (group II) with severe HRF. In group I the mean values of EF, SV and CO were significantly higher than in the group II. Our results showed a significant increase of PTX-3 in group II patients at 24h of life when compared to group I. Taking patients all together (n=40), we found a significant (R=-73) reverse correlation between EF and serum values of PTX-3. PTX-3 in our patients with HRF is affected by the severity of the hypoxic insult and correlate with the cardio-vascular impairment.

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