IMR Press / FBE / Volume 2 / Issue 2 / DOI: 10.2741/E131

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Liver cell-mediated alleviation of acute ischemic myocardial injury
Show Less
1 Biomedical Engineering Department, Northwestern University, Evanston, IL 60208-3107, USA

*Author to whom correspondence should be addressed.

Academic Editor: Shu Liu

Front. Biosci. (Elite Ed) 2010, 2(2), 711–724; https://doi.org/10.2741/E131
Published: 1 January 2010
(This article belongs to the Special Issue Molecular and biomechanical bases of vascular tissue engineering)
Abstract

Cardiomyocyte injury occurs in myocardial ischemia, resulting in impairment of cardiac function. As the endogenous protective function of adult cardiomyocytes is limited, nonmyocytic cells may be activated to protect myocardium from ischemic injury. In this investigation, we demonstrated in a mouse model of myocardial ischemia that the liver was able to respond to myocardial ischemia to upregulate a number of genes encoding secreted proteins, mobilize its cells, and release cell contents into the circulatory system. These naturally occurring mechanisms suggested a possible cardioprotective role for myocardial ischemia-conditioned liver cells and inspired us to develop cardioprotective therapies based on these mechanisms. We demonstrated that administration of liver cell extract derived from myocardial ischemic mice, but not sham control mice, resulted in a significant reduction in acute myocardial infarction as well as the density of TUNEL+ cells in ischemic myocardium compared to administration of PBS at 2, 6, 12, and 24 hrs. These observations suggest that liver cells may respond to myocardial ischemia to express cardioprotective factors, which may be identified and used for alleviating myocardial infarction.

Keywords
Cardioprotection
myocardial Ischemia
Hepatocytes
Share
Back to top