IMR Press / FBE / Volume 2 / Issue 2 / DOI: 10.2741/E126

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

In vitro drug interactions of gallates with antibiotics in Staphylococcus Aureus

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1 Advanced Design and Modeling Lab, Nanyang Technological University, Singapore
2 Biomedical Engineering Research Centre, Nanyang Technological University, Singapore
3 Molecular Diagnostic Centre, National University Hospital, Singapore
4 OmicsVista, Singapore

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2010, 2(2), 668–672; https://doi.org/10.2741/E126
Published: 1 January 2010
Abstract

The antimicrobial activities of tetracycline, mupirocin, and fusidic acid are tested in combination with Epicatechin Gallate (ECG), and Ethyl Gallate (EG) using 2 Methicillin resistant (MRSA) and 2 Methicillin sensitive (MSSA) strains of Staphylococcus aureus. Sub-inhibitory concentration of EG at 256mg l-1 is found to be synergistic when used in combination with tetracycline, mupirocin, and fusidic acid; and a sub-inhibitory concentration of ECG at 32 mg l-1 is found to be synergistic with tetracycline in all the four Staphylococcus aureus strains tested. The synergistic combinations reduce the MICs of all the above three antibiotics by 4 fold. Combining ECG at 32mg l-1 with mupirocin, reduces the MIC of mupirocin by four fold in MSSA C1 strain. 74% of the combinations show consistent results in both time-kill assay and checkerboard method. The identified combinations may lead towards novel therapeutic interventions for treating MRSA infections.

Keywords
MRSA
Therapeutic Intervention
Antibiotics
Drug
Resistance
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