IMR Press / FBE / Volume 2 / Issue 2 / DOI: 10.2741/E121

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

A comparative study on two phenylboronic acid based glucose-sensitive hydrogels
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1 School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
2 Department of Pharmaceutics, PLA General Hospital, Beijing 100853, China
3 Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, US

*Author to whom correspondence should be addressed.

Academic Editor: Xueji Zhang

Front. Biosci. (Elite Ed) 2010, 2(2), 657–667;
Published: 1 January 2010
(This article belongs to the Special Issue Biosensors and their applications)

Two phenylboronic acid based glucose-sensitive hydrogels, A•PBA-DMAPMA-EGDMA and A•PBA-PEG, were initially prepared by free-radical polymerization. Swelling properties of the gels were studied by determining the diameter changes in different buffer solutions, with or without glucose or fructose. The hydrogels were designed as "valves" to control the flow of glucose solutions. The results showed that gel A•PBA-DMAPMA-EGDMA was sensitive to pH and glucose, but not to fructose. It shrunk in weak basic solution and the addition of glucose made it shrink more. In this gel PBA moiety and glucose is supposed to form a 1:2 bis-bidentate complex. Hydrogel A•PBA-PEG was sensitive to pH, glucose and fructose, all of which made it swell in weak basic solution. A 1:1 complex is believed to form between PBA and glucose/fructose in this gel. All the stimuli-responses are reversible and the glucose-responses occurred in the range of the physiological/pathological glucose level. Both A•PBA-DMAPMA-EGDMA and A•PBA-PEG exhibited sufficient volume change to the alteration of glucose concentration and could be employed as a "valve" to control liquid flow in weak basic solution.

Glucose-sensitive hydrogel
Phenylboronic acid
Poly(ethylene glycol)
Self-regulated drug delivery
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