IMR Press / FBE / Volume 2 / Issue 2 / DOI: 10.2741/E114

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Haemostatic gene polymorphisms in young Sardinian with acute myocardial infarction 

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1 Department of Biomedical Sciences and Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Italy
2 Laboratory Analysis Unit , C. Zonchello, Italy
3 UTIC, ASL N.3 Nuoro, Italy
4 INRCA Ancona, Italy
5 Department of Pharmacology and Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Italy
6 National Laboratory of the National Institute of Biostructures and Biosystems, Osilo, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Giovanni Li Volti

Front. Biosci. (Elite Ed) 2010, 2(2), 559–565; https://doi.org/10.2741/E114
Published: 1 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

Although the role of environmental factors in the development of acute myocardial infarction (AMI) has been clearly established, the role of genetic factors is still undefined. The aim of this study was to investigate the association between various gene polymorphisms in the haemostatic system and the risk of myocardial infarction in a very genetic restricted area population of Sardinian young adults with AMI. The study case-control involved 71 patients who had survived a first MI at a mean age of 47,2 years and 150 healthy subjects. No differences in the allele or genotype frequencies were seen between the study groups for the fibrinogen, prothrombin, factor V, factor VII, vWF, TM, PAI-1, TPO gene, and PLA and HPA-2 genes polymorphisms. Indeed differences statistically significant were detected for A5709G in the TPO gene (P= 0,041), and I/D dimorphism in the eNOS gene (P= 0,016). We therefore conclude that among all the investigated polymorphisms only the 5709G and eNOS4a alleles seem to confer protection against MI in the young age of Sardinian people.

Keywords
Young
Myocardial Infarction
Genetic Polymorphism
Coagulation
Platelets
Fibrinolysis
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