IMR Press / FBE / Volume 2 / Issue 2 / DOI: 10.2741/E107

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Clinical biomarkers in esophageal adenocarcinoma
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1 Section of General Surgery and Oncology, Department of General Surgery, University Medical School of Catania, Italy, Ospedale Vittorio Emanuele Via Plebiscito, 628, 95100 Catania, Italy
2 Section of Thoracic Surgery, Department of Thoracic Surgery; University Medical School of Catania, Italy, Ospedale Garibaldi, P.O. S. Luigi, Viale Fleming 24, 95100 Catania Italy

*Author to whom correspondence should be addressed.

Academic Editor: Giovanni Li Volti

Front. Biosci. (Elite Ed) 2010, 2(2), 489–494; https://doi.org/10.2741/E107
Published: 1 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

This review describes genetic and molecular changes related to adenocarcinoma of the esophagus and gastroesophageal junction (GEJ) with emphasis on prognostic value and possibilities for targeted therapy in clinical setting. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma.

Keywords
Biomarkers
Esophageal Adenocarcinoma
Barrett’s Esophagus
Esophageal Dysplasia
Predictive Tests
Review
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