IMR Press / FBE / Volume 2 / Issue 2 / DOI: 10.2741/E106

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Does exercise really induce lymphocyte apoptosis?
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1 Department of Kinesiology, Recreation, and Sport; Western Kentucky University; Bowling Green, Kentucky
2 Department of Health and Human Performance; Laboratory of Integrated Physiology; University of Houston; Houston, Texas
3 Department of Health and Human Performance; Texas Obesity Research Center; University of Houston; Houston, Texas

*Author to whom correspondence should be addressed.

Academic Editor: Richard Simpson

Front. Biosci. (Elite Ed) 2010, 2(2), 478–488;
Published: 1 January 2010
(This article belongs to the Special Issue Exercise effects on immunity: cellular and molecular responses)

While the stress associated with acute exercise has been reported to induce significant lymphocyte apoptosis, not all investigations have confirmed this finding. Regardless of animal or human subjects, exercise-induced lymphocyte apoptosis may be induced via an external receptor-mediated pathway, or internally via the mitochondria through an oxidative-mediated pathway. On the other hand, investigators reporting no effect of acute exercise on lymphocyte apoptosis speculate that cell death may be dissociated from these pathways, and explain exercise lymphocytopenia by selective migration of the lymphocytes back into the lymphoid pools. Discrepancies may be due to sensitivity issues related to the methodology used to assess cell death. Limitations to various methods used to evaluate exercise-induced lymphocyte apoptosis are detailed, and considerations for a new technique are outlined.

Leukocyte cell death
Apoptotic response
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