IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E87

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Comparison of methods for statistical analysis of combination studies

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1 School of Mathematics, University of Manchester, UK

*Author to whom correspondence should be addressed.

Academic Editor: William R. Greco

Front. Biosci. (Elite Ed) 2010, 2(1), 250–257; https://doi.org/10.2741/E87
Published: 1 January 2010
Abstract

This paper is concerned with the statistical analysis of data obtained in studies of the joint action of drugs. The three methods that are compared are illustrated on real data (1), using the statistical package SAS. It is argued that while the results obtained using these methods do not differ substantially, the method allowing for estimating simultaneously all required parameters is to be preferred. It allows for a statistical test for the significance of the joint action of the drug combinations to be carried out.

Keywords
Combination index
Drug combination
Interaction index
Ray design
Review
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