IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E83

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Correlation of the virulence of CSFV with evolutionary patterns of E2 glycoprotein
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1 The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education and The State Key Laboratory of Biomembrane and Membrane Bio-engineering, Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, P. R. China
2 The Center for Theoretical Biology, Peking University, Beijing 100871, P. R. China
3 Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, P.R.China
4 Neuroscience Research Institute and Infectious Disease Center, Health Science Center, Peking University, Beijing 100191, P.R.China

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2010, 2(1), 204–220; https://doi.org/10.2741/E83
Published: 1 January 2010
Abstract

Infection with classical swine fever virus (CSFV) is costly to the livestock industry. Several genomic sequences including velogenic strains and low virulent strains have been identified. However, the reasons for the virulence of the virus have remained unclear. Based on selective pattern and pressure strength, we classified all genes of CSFV into three classes. Among these genes, the E2 gene was under the strongest positive selection. Based on the analysis of 85 representative E2 gene sequences, the location and intensity of positive selection in CSFV isolates from group one and group two were identified. These results suggest that these two groups employ evolutionary difference. Moreover, the mutations, potentially driven by positive selection, can be correlated with the virulence of CSFV by altering the conformation and function of E2 and/or changing its glycosylation pattern. Based on these results, a model for the evolution of virulence of CSFV is proposed. The results provide a link between epidemiology and the gene function of CSFV, and may shed light on the molecular mechanism underlying the variation of CSFV virulence.

Keywords
Classical Swine Fever Virus
Virulence
Evolutionary Analysis
E2 glycoprotein
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