IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E78

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

S100B protein and near infrared spectroscopy in preterm and term newborns
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1 Department of Maternal, Fetal and Neonatal Medicine, G Garibaldi Hospital, Catania, Italy
2 Perinatal Research Laboratory, Department of Cardiac Surgery, S. Donato Milanese University Hospital, S. Donato Milanese
3 Department of Fetal Maternal and Neonatal Medicine, San Gerardo Hospital, Monza
4 Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy
5 Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena
6 Departments of Fetal Maternal and Neonatal Medicine C. Arrigo Children’s Hospital, Alessandria, Italy
7 Pediatrics and Neuroscience Giannina Gaslini Children’s University Hospital, Genoa, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2010, 2(1), 159–164;
Published: 1 January 2010

Cerebral monitoring constitutes an emerging issue in perinatal medicine. Near Infrared Spectroscopy (NIRS) monitors brain oxygenation status in sick infants although data in healthy infants are lacking. The present study investigates whether NIRS parameters change according to gestational age and correlate with S100B protein. We recruited 64 healthy newborns (weeks' gestation: 30-42 wks) in which we performed in the first 6-hours after birth routine clinical, radiological and laboratory variables, cerebral oxygen saturation (rSO2), fractional cerebral tissue oxygen extraction (FTOE) values and S100B urine assessment. rSO2 and FTOE correlated (R=-0.73; R=0.51; P less than 0.01, for both) with gestational age. Highest rSO2 and the lowest FTOE peaks (P less than 0.001) were found at 30-33 wks. From 34 wks onwards, rSO2 progressively decreased and FTOE increased reaching their lower dip/peak (P less than 0.001) at 38-39 weeks. A significant correlation between S100B and NIRS parameters (rSO2: r=0.77; FTOE: r=-0.69; P less than 0.01) has been found. The present study shows that NIRS parameters and S100B protein correlation may be of help in brain function monitoring.

Brain Oxygenation
Brain Damage
Cerebrovascular System
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