IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E71

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Biochemical characteristics and risk factors in non-alcoholic fatty liver
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1 Department of Clinical Biochemistry, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing, China, 100853

*Author to whom correspondence should be addressed.

Academic Editor: Xueji Zhang

Front. Biosci. (Elite Ed) 2010, 2(1), 105–110; https://doi.org/10.2741/E71
Published: 1 January 2010
(This article belongs to the Special Issue Biosensors and their applications)
Abstract

Non-alcoholic fatty liver disease (NAFLD) is a condition associated with metabolic disturbances. The aim of the present study was to investigate the biochemical characteristics and risk factors for NAFLD. The study was carried out in a total of 881 subjects diagnosed by ultrasonography. NAFLD occurred mainly in middle-aged individuals, with a prevalence of 63.1%. Multiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD. Subjects with NAFLD were obese, hypertensive and often had signs of disturbances in lipid and glucose metabolism and abnormalities in hepatic functions. These findings show risk factors in the development and offer opportunities for prevention of NAFLD.

Keywords
non-alcoholic fatty liver disease
characteristics
risk factors
urban population
Chinese
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