IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E66

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The relation of S100beta and metabolic and endocrine responses to acute fetal hypoxemia
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1 Department of Physiology University of Cambridge, Cambridge, UK
2 Department of Pediatrics and Neuroscience, Giannina Gaslini Children’s University Hospital, Genoa I-16147, Italy
3 Department of Maternal Fetal and Neonatal Health, G. Garibaldi Hospital Catania, Italy

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2010, 2(1), 59–67;
Published: 1 January 2010

Elevations in S100beta protein in umbilical cord blood have been proposed as a reproducible marker of fetal stress, leading to cell damage within the central nervous system. However, it remains unknown whether fetal S100beta concentrations correlate with established endocrine and metabolic indices of fetal distress. Hence, in the late gestation ovine fetus, plasma concentrations of S100beta, adrenocorticotropic hormone (ACTH), cortisol, neuropeptide Y (NPY), and catecholamines and blood concentrations of glucose and lactate were measured during acute hypoxemia. Under general anesthesia, 5 sheep fetuses were chronically instrumented with catheters and subjected 5 days later to 1h normoxia, 0.5h hypoxemia and 1h recovery. Plasma samples were taken during each experimental period. Hypoxemia induced significant falls in PaO2 with increases in fetal plasma concentrations of ACTH, cortisol, catecholamines and NPY, and elevations in blood glucose and lactate, all of which showed significant positive relationships with fetal plasma S100beta concentrations. Hence, evaluation of S100beta may provide a valuable clinical tool in the assessment of fetal well-being in suspected complicated pregnancies.

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