IMR Press / FBE / Volume 2 / Issue 1 / DOI: 10.2741/E59

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Molecular interactions in extracellular matrix of tendon
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1 Department of Experimental Biomedical and Clinical Sciences (DSBSC), University of Insubria, Varese, Italy
2 Department of Orthopaedic and Traumatology, University of Insubria, Varese, Italy
3 Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Stoke on Trent, Staffordshire, UK

*Author to whom correspondence should be addressed.

Academic Editor: Nicola Maffulli

Front. Biosci. (Elite Ed) 2010, 2(1), 1–12; https://doi.org/10.2741/E59
Published: 1 January 2010
(This article belongs to the Special Issue Tendons: the next frontier)
Abstract

Tendon is a poorly vascularized and highly specialized connective tissue containing few scattered cells that play an important role in the musculoskeletal apparatus by resisting mechanical stress. Because of the slow rate of the metabolism of its molecular components, the tendon gradually loses its mechanical properties and may rupture upon an array of physical activities. In this report, we discuss the molecular changes involved in the extracelluar matrix-tendon interactions leading to tissue degeneration and rupture.

Keywords
Tendon
Extracellular matrix
Gene expression
Collagen
Matrix Metalloproteases
Tissue inhibitor of Matrix Metalloproteases
Tendinopathy
Review
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