The aim of the present investigation was to evaluate the efficacy of an antibacterial coating of implant-abutment prosthetic junctions by real time measurement of Volatile Organic Compounds (VOCs). A total of 20 patients and 40 internal prosthetic junction implants were evaluated in the present investigation: 20 fixtures with antibacterial internal coating (Test) and 20 without treatment (Control). The VOCs measurements were evaluated at the baseline (T{}_0) after the cover unit unscrewing, after 7 days (T{}_1) and at 14 days (T{}_2). No significant difference were detected at T{}_0 (baseline), as Test and Control groups showed a VOCs max peak mean respectively of 2.15 \pm 0.71 and 2.21 \pm 0.69 (p > 0.05). At T{}_1 and T{}_2 as significant difference between the Test and Control Groups was detected (p 0.01). At T{}_2 the Test max peak was 2.29 \pm 0.73 and the Control was 3.65 \pm 0.91 (p 0.01). The antibacterial internal coating demonstrated the capacity to prevent microbial VOCS activity at the level of the implant internal chamber and could be useful for long-term peri-implant tissue health.