IMR Press / FBE / Volume 13 / Issue 1 / DOI: 10.2741/876

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Therapeutic applications of transdermal microneedles
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1 College of Pharmacy, University of Iowa, Iowa City, IA, 52246
2 Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia
3 College of Professional Studies, Northeastern University, Boston, MA, USA – 02115
4 Independent Clinical Pharmacologist, Billerica, MA 01821, USA
5 Department of Anatomy, Faculty of Medicine, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia
Send correspondence to: Arunachalam Muthuraman, Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia. Tel: 60-1136293386, Fax: 604-429 8009, E-mail: arunachalammu@gmail.com
Front. Biosci. (Elite Ed) 2021, 13(1), 158–184; https://doi.org/10.2741/876
Published: 1 October 2020
Abstract

Transdermal drug-delivery systems (TDDS) offer an attractive alternative to the oral route for delivery of biotherapeutics. Technological advancements in the past few decades have revolutionized the fabrication of micro-structured devices including creation of microneedles (MC). These devices are used for delivering peptides, macromolecules such as proteins and DNA, and other therapeutics through the skin. Here, we review the current use of MCs as a cost effective method for the self-administration of therapeutics. We will then review the current and common use of MCs as an effective treatment strategy for a broad range of diseases and their utility in the generation of effective vaccination delivery platforms. Finally, we will summarize the currently FDA approved MCs and their applications, along with the ongoing clinical trials that use such devices.

Keywords
Alzheimer disease
Diabetes mellitus
Immunity
Obesity
Transdermal drug delivery
vaccine therapy
Review
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