IMR Press / FBE / Volume 12 / Issue 1 / DOI: 10.2741/E862

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Amplification of speckle-microscope signal by using gold nanoparticle stable of contents
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1 Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia
2 Saratov State University, Saratov, 410012, Russia
3 Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, 410049, Russia
4 Saratov State Agrarian University, Saratov, 410012, Russia
Send correspondence to: Valentina A. Feodorova, Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia, Tel: 7-8452-200-825, Fax: 7-8452-200-830, E-mail: feodorovav@mail.ru
Front. Biosci. (Elite Ed) 2020, 12(1), 126–138; https://doi.org/10.2741/E862
Published: 1 January 2020
(This article belongs to the Special Issue Global control of infectious disesses)
Abstract

Speckle-microscopy is used for the detection of Chlamydia trachomatis in aqueous suspensions or on slides. Monoclonal antibody tagged with gold nanoparticles that form biospeckles have also been used with a small number of scatterers. By devising a prototype of laser scanning speckle-microscope, we now demonstrate that the signal of speckle microscope can be significantly amplified in the presence of gold nanoparticles. This enhancement of signal emitted from gold nanoparticles offers a better approach to the detection of C. trachomatis.

Keywords
Chlamydia trachomatis
Gold Nanoparticles
Laser
Speckle
Microscopy
Figures
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