IMR Press / FBE / Volume 12 / Issue 1 / DOI: 10.2741/E861

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Predictive value of coronary artery calcium score in cardiovascular disease
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1 Department of Radiology, Baotou Central Clinical Medicine College, Inner Mongolia Medical University, Inner Mongolia 014040, China
2 Department of Cardiovascular Medicine, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200135, China
3 Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
4 Baotou Medical Collage, Inner Mongolia 014040, China
Send correspondence to: Kai Sun, Department of Radiology, Baotou Central Clinical Medicine College, Inner Mongolia Medical University, Inner Mongolia 014040, China, Tel: 86-018804723588, Fax: 86-2164085875, E-mail: Henrysk@163.com
Front. Biosci. (Elite Ed) 2020, 12(1), 113–125; https://doi.org/10.2741/E861
Published: 1 January 2020
Abstract

We investigated coronary heart disease (CHD) and cardiovascular disease (CVD) event rates in a diverse population with a coronary artery calcium score (CACS) of 0 and the role of CACS in the detection of subclinical noncalcified atherosclerotic plaque. A total of 15,884 participants in five studies were included in this meta-analysis. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated. The results showed that CHD incidence significantly increased with increased CACS (HR=0.05, 95% CI 0.03–0.06, Z=5.82, P=0.002). The CHD rate was low and further increased with CACS of 101–300. With CACS >300, the CHD rate was highest. Similarly, CVD rate was low with CACS of 0, increased with CACS of 1–100 (HR=0.03, 95% CI 0.01–0.06, Z=1.66, P=0.096), and further increased with CACS of 101–300. With CACS >300, the CVD rate was highest. Clinical evidence indicated that the higher the CACS, the higher the CHD and CVD rates, while the CVD rate does not always decreased compared with CHD rate with the same CACS, especially with CACS of 0.

Keywords
Computed tomography
CT
Coronary artery calcium score
CACS
Coronary heart disease
CHD
Cardiovascular disease
CVD
Figures
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