IMR Press / FBE / Volume 12 / Issue 1 / DOI: 10.2741/E858

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Preventative effects of alpha-naphtho flavone in vascular dementia
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1 Pharmacology Department, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru-570 015, Karnataka, India
2 Pharmacology Unit, Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia
Send correspondence to: Arunachalam Muthuraman, Pharmacology Department, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru-570 015, Karnataka, India. Tel: 0821-2548353; Fax: 0821-2548359; E-mail: arunachalammu@gmail.com
Front. Biosci. (Elite Ed) 2020, 12(1), 79–94; https://doi.org/10.2741/E858
Published: 1 January 2020
Abstract

Vascular dementia (VaD) refers to the loss of reasoning, planning, judgment, and memory as a result of reduced blood flow, inflammation, activation of immune cells, and neurodegenerative processes. Here, we tested the preventive effects of alpha-naphthoflavone (ANF) on a model of vascular dementia induced by four-vessel occlusion (4VO) in rats. Animals were treated orally for 5 consecutive days with 10 mg/kg of donepezil (a traditional therapeutic drug) and 40 and 80 mg/kg ANF. The treatment with ANF exerted effects that were similar to those induced by donepezil. This included prevention of cognitive impairment, alterations in the plasma levels of homocysteine and nitrate and the activity of acetylcholinesterase and myeloperoxidase and the tissue level of glutathione, and thiobarbituric acid reactive substances in the brain tissues. These findings suggest that herbal-derived ANF is as effective as traditional drugs in vascular dementia.

Keywords
Alpha-naphthoflavone
Carotid occlusion
Homocysteine
Ratus norvegicus
Vascular dementia
Vertebral artery
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