IMR Press / FBE / Volume 12 / Issue 1 / DOI: 10.2741/E857

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role of miRNA clusters in epithelial to mesenchymal transition in cancer
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1 Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India
Send correspondence to: Shama Prasada Kabekkodu, Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal-576104, Karnataka, India, Tel: 0820-2922058, Fax: 91-820-2571919, E-mail: shama.prasada@manipal.edu
Front. Biosci. (Elite Ed) 2020, 12(1), 48–78; https://doi.org/10.2741/E857
Published: 1 January 2020
Abstract

Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.

Keywords
MicroRNA cluster
EMT
Signaling pathway
Cancer
EMT-TFs
Figures
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