IMR Press / FBE / Volume 12 / Issue 1 / DOI: 10.2741/E855

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Fucoidan serves a neuroprotective effect in an Alzheimer’s disease model
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1 Division of vector control, Entomology Research Institute, Loyola College, Chennai-600034, Tamil Nadu, India
2 Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode - 637 205, Tamil Nadu, India
3 Center of Advanced Study in Crystallography and Biophysics, University of Madras, Chennai-600 025, Tamil Nadu, India
4 Department of Zoology, St. Thomas College, Kottayam-686 574, Kerala, India
5 Department of Biomedical Science, Alagappa University, Karaikudi-630 003, Tamil Nadu, India
6 Xavier Research Foundation, St. Xavier’s College, Palayakottai-627001, Tamil Nadu, India
Send correspondence to: Savarimuthu Ignacimuthu, Division of vector control, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, 600034, India, Tel: 044-28178348, Fax: 004-28174644, E-mail: rajivsuba@gmail.com
Front. Biosci. (Elite Ed) 2020, 12(1), 1–34; https://doi.org/10.2741/E855
Published: 1 January 2020
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes memory and cognitive deficits. The present study was carried out to evaluate the protective effects of fucoidan in monocrotophos induced AD in Drosophila melanogaster. In silico studies showed that fucoidan exhibited binding energy of -9.3 kcal with proteins. Consistent with this, fucoidan, in a dose and time-dependent fashion, had inhibitory activity against cholinergic and monoamine-metabolized enzymes in vitro. Fucoidan inhibited the increase in total mRNA and protein in monocrotophos fed flies and prevented changes in biochemicals, neurochemicals and latency time of locomotor, learning and memory induced by monocrotophos. Together, the findings show that fucoidan serves a neuroprotective effect in Alzheimer’s disease model in D. melanogaster.

Keywords
Molecular docking
fucoidan
monocrotophos
PC12 human neuroblastomal cells
Drosophila melanogaster and Alzheimer’s disease
Figures
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