IMR Press / FBE / Volume 11 / Issue 1 / DOI: 10.2741/E853

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Epithelial-to-mesenchymal transition: Event and core associates in bladder cancer
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1 Department of Biochemistry, University of Lucknow, Lucknow-226007, India
Send correspondence to: Minal Garg, Department of Biochemistry, University of Lucknow, Lucknow, 226007, India, Tel: 91-9335820857, Fax:91-522-2348968, E-mail: minal14@yahoo.com
Front. Biosci. (Elite Ed) 2019, 11(1), 150–165; https://doi.org/10.2741/E853
Published: 1 June 2019
Abstract

Urothelial carcinoma of the bladder (UCB) shows different biological outcomes, diverse biological propensities for invading the muscularis as well as epithelial-to-mesenchymal transition (EMT), a dynamic key event during developmental processes, wound healing, and tissue repair. The EMT core molecules include EMT-activating transcription factors (EMT-ATFs), and a host of downstream effectors and target genes including extracellular inducers and growth factors. Here, we describe molecular regulatory determinants of mesenchymal-to-epithelial transition (MET) and more specifically EMT that allows a subset of urothelial cancer cells to gain mesenchymal traits with self-renewal potential. EMT accelerates tumor progression and poses a clinical challenge to anticancer therapies. Targeting the populations of tumor-initiating cells and those with a metastable phenotype provide the basis for the development of more reliable risk assessment of tumor progression and risk, and better treatment strategies of UCB.

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