IMR Press / FBE / Volume 11 / Issue 1 / DOI: 10.2741/E842

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson’s disease
Show Less
1 Research Scholar, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu 600073, India
2 Department of Anatomy,Velammal Medical College, Madurai, Tamil Nadu 625009, India
3 Sree Balaji Medical College, Chennai, Tamil Nadu 600044, India
4 Department of Anatomy, Sree Balaji Medical College, Chennai, Tamil Nadu 600044, India
Send correspondence to: Srinivasagam Rajasankar, Department of Anatomy, Velammal Medical College and Hospital, Madurai, Tamil Nadu 625009, Tel:999454534, Fax:04522970176, E-mail: srsanatomy@gmail.com
Front. Biosci. (Elite Ed) 2019, 11(1), 12–19; https://doi.org/10.2741/E842
Published: 1 January 2019
Abstract

Rotenoneis a pesticide that has been shown to induce the pathological symptoms ofParkinson'sdisease(PD) in both cellular and animal models. In this study, we investigated the protective effect of Agaricus blazei extract onrotenone-induceddopaminergic degeneration and apoptosisin mice model. A. blazei extract blocked therotenone-mediated diminution of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT 2) expression and the downregulation of Bcl-2 and the upregulation of Bax, caspases-3, -6, -8 and caspase-9. Present data suggest that A. blazei extract plays a crucial role in regulation of proteins expression such as DAT and VMAT2 and pro-apoptotic and anti-apoptotic in Parkinsonism. In conclusion, the present study shows that A. blazei extract act as potential neuroprotective agent in the management of Parkinsonism.

Figures
Figure 1
Share
Back to top