IMR Press / FBE / Volume 10 / Issue 3 / DOI: 10.2741/E838

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

High incidence of BRAFV600 mutation in Indian patients with head and neck cancer

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1 Department of Integrative Biology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, India

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(3), 520–527; https://doi.org/10.2741/E838
Published: 1 June 2018
Abstract

In cancer cells, BRAF is frequently mutated at codon 600 (V600) leading to the replacement of valine amino acid with other amino acids. The current study was performed to assess the prevalence of BRAFV600 mutation in Indian patients with head and neck squamous cell carcinoma (HNSCC). Among the patients, 27% were homozygous, and 71% were heterozygous for the mutation and only 2% showed a wild genotype. Since identification of BRAFV600 mutation in cancer patients is used for selection of the therapeutic agents, this study shows that all Indian patients with HNSCC must be screened for this mutation.

Keywords
BRAF
Head
Neck
Cancer
Mutation
PCR-RFLP
V600
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