IMR Press / FBE / Volume 10 / Issue 3 / DOI: 10.2741/E837

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

MHC-B haplotypes impact susceptibility and resistance to RSV-A infection

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1 Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2 Disease Genetics and Biotechnology Lab, CARI, Izatnagar, UP-243 122, India
3 Tumor Immunology Lab, IVRI, Izatnagar, UP-243 122, India
4 CADRAD, IVRI, Izatnagar, UP-243 122, India
5 Animal Science Department, Rohilkhand University, Bareilly (UP), India
6 Department of Pharmacology and Experimental Therapeutics, The University of Toledo, Toledo, OH 43614, USA

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(3), 506–519; https://doi.org/10.2741/E837
Published: 1 June 2018
(This article belongs to the Special Issue Cell death mechanisms)
Abstract

We investigated the impact of haplotype of major histocompatibility complex (MHC)-B on the outcome of infection of Synthetic Dam Line (SDL) broiler strain with Rous Sarcoma Virus (RSV). Genomic analysis of MHC-B haplotypes, revealed a total of 12 known standard haplotypes that constituted to twenty-five different genotypes and one new haplotype of 217 bp size, designated BX. The inoculation of RSV-A in SDL chicks resulted in the development of tumors of progressive or regressive phenotypes with varying tumor profile index (TPI). Haplotypes B2, B21 and B22 had low TPI scores (1 or 2) with less mortality and were resistant to RSV-A tumor. The haplotypes B13, B13.1., B15, B15.1. and B15.2. had significantly higher TPI scores (5 or 6), indicating a susceptibility to RSV-A. The genotype, Bx /Bx, had a mean TPI score of 3.67 ± 1.33, which was closer to the resistant haplotype. Sequence analysis of the new haplotype (BX) revealed 99.5% similarity with B2 haplotype. Metastases was observed in 44% of chicks and comprised of mixed fibrosarcoma and myxosarcoma.

Keywords
Major histocompatibility complex
Rous sarcoma virus–A
synthetic dam line
tumors
susceptibility
resistance
metastasis
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