IMR Press / FBE / Volume 10 / Issue 3 / DOI: 10.2741/E835

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Myricetin attenuates neurodegeneration and cognitive impairment in Parkinsonism

Show Less
1 Research and Development Centre, Bharathiar University, Coimbatore-641046, Tamilnadu, India
2 PG and Research Department of Biochemistry, Rajah Serfoji Government College, Thanjavur-613005, Tamilnadu, India
3 Department of Biotechnology, School of Biosciences, Periyar University, Salem-636011, Tamilnadu, India

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(3), 481–494; https://doi.org/10.2741/E835
Published: 1 June 2018
Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disease due to dopaminergic neuron degeneration. It mostly affects the aged population, leads to memory decline and loss of motor coordination. The present study investigates the neuroprotective role of myricetin a flavonol isolated from the brown seaweed Turbinaria ornata in rotenone induced Drosophila model of PD. Rotenone administration led to dopaminergic neuronal degeneration, dopamine depletion, impaired muscular coordination, gait disturbances, memory decline oxidative stress and apoptosis. Ingestion of myricetin by Drosophila significantly prevented rotenone induced neuronal degeneration. These results confirm that myricetin exerts neuroprotective effect in experimental PD.

Keywords
Myricetin
Rotenone
Oxidative stress
Apoptosis
Styrofoam bead test
Parkinson’s disease
Share
Back to top