IMR Press / FBE / Volume 10 / Issue 3 / DOI: 10.2741/E831

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Thraatchathi Chooranam, protects cardiomyocytes against oxidative stress

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1 Department of Biochemistry, PRIST University, Thanjavur-613 403, TN, India
2 Research and Development Centre, Bharathiar University, Coimbatore – 641046, TN, India
3 Tissue engineering group, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Faculty of medicine, University of Malaya, Malaysia
4 Dept of Pharmacology, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysuru– 570015, KA, India

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(3), 437–448; https://doi.org/10.2741/E831
Published: 1 March 2018
Abstract

Thraatchathi Chooranam (TC), is a polyphenol-rich Indian traditional medicine. Present study was undertaken to investigate the effects of TC against H2O2 induced oxidative stress and apoptotic damage in H9C2 cardiomyocytes. Cell viability assay indicated relative safety (IC50= 488.10±12.04 μg/ml) of TC. Pretreatment of cells with TC upregulated anti-apoptotic Bcl2, and anti-oxidants TRX1 and TRXR and downregulated Bax and HIF-α and inflammatory genes iNOS and TNF-α. Together, these findings show that TC has both anti-oxidant and anti-apoptotic properties. Further studies may be considered to identify the bioactive principle(s) and precise mechanisms of action of TC.

Keywords
Thraatchathi Chooranam
Polyphenols
Cardiovascular Disease
Hydrogen peroxide
Antiapoptotic
Oxidative stress
Cytokine
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