IMR Press / FBE / Volume 10 / Issue 3 / DOI: 10.2741/E830

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Prostate cancer susceptibility and growth linked to Y chromosome genes

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1 Department of Urology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, USA
2 Department of Urology, Menofia University, Shebin Al Kom, Egypt

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(3), 423–436; https://doi.org/10.2741/E830
Published: 1 March 2018
(This article belongs to the Special Issue Recent progress in reproductive biology)
Abstract

The role of Y chromosome in prostate cancer progression and incidence is not well known. Among the 46 chromosomes, Y chromosome determines the male gender. The Y chromosome is smaller than the X chromosome and contains only 458 genes compared to over 2000 genes found in the X chromosome. The Y chromosome is prone to high mutation rates, created exclusively in sperm cells due to the highly oxidative environment of the testis. Y chromosome harbors epigenetic information, which affects the expression of genes associated with the incidence and progression of prostate cancer. In this review, we focus on Y chromosome related genetic abnormalities, likely to be involved in the development and progression of prostate cancer.

Keywords
Y chromosome
Prostate cancer
DYZ1
Cancer Genetics
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