IMR Press / FBE / Volume 10 / Issue 2 / DOI: 10.2741/E827

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Nanoantibiotics: Future nanotechnologies to combat antibiotic resistance

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1 Department of Microbiology, Government College University, Allama Iqbal road, 38000, Faisalabad, Pakistan
2 Institute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, 610054 Chengdu, China
3 Department of Physics, GC University, 38000, Faisalabad
4 Department of Bioinformatics and Biotechnology, Government College University, Allama Iqbal road, 38000, Faisalabad, Pakistan
5 Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia
6 National Institute of Laser and Optronics, Nilore, Islamabad, Pakistan
7 Quaid e Azam Medical College Circular Road, 63100, Bahawalpur

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(2), 352–374; https://doi.org/10.2741/E827
Published: 1 March 2018
Abstract

The discovery of antibiotics was hailed as a historic breakthrough for the human race in the fight against bacterial and malignant infections. However, in a very short time, owing to their acute and aggressive nature, bacteria have developed resistance against antibiotics and other chemotherapeutics agents. Potentially, this situation could again result in bacterial infection outbreaks. Metal and metal oxide nanoparticles have been proven as better alternatives; the combination of antibiotics and metal oxide nanoparticles was shown to decrease the toxicity and enhance the antibacterial, antiviral, and anticancer efficacy of the agents. This review provides a detailed view about the role of metal and metal oxide nanoparticles in the treatment of infections in conjunction with antibiotics, their modes of action, and synergism. In addition, the problems of multidrug resistance are addressed and will allow the development of a comprehensive, reliable, and rational treatment plan. It is expected that this comprehensive review will lead to new research opportunities, which should be helpful for future applications in biomedical science.

Keywords
Antibiotic resistance
Metallic Nanoparticles
Synergism
Review
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