IMR Press / FBE / Volume 10 / Issue 2 / DOI: 10.2741/E824

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Effects and mechanisms of actions of phytochemicals on Alzheimer’s disease neuropathology

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1 Department of Psychology, Loma Linda University, 11130 Anderson Street. Loma Linda, California 92350, USA

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(2), 300–333; https://doi.org/10.2741/E824
Published: 1 January 2018
Abstract

Alzheimer’s disease affects millions of people, yet, there are only a limited number approaches for it pharmacological treatment. Thus, identifying factors that decrease the risk of developing Alzheimer’s disease is of paramount importance. A growing body of epidemiological and experimental evidence suggests that dietary fruits and vegetables have neuroprotective effects against the harmful effects of oxidative stress, neuroinflammation, and aging. These effects are mediated by various phytochemical compounds found in plants that exhibit antioxidant, anti-inflammatory, and other beneficial properties. This review addresses epidemiological and experimental evidence for the effects and potential mechanisms of several commonly consumed phytochemicals on neuropathology and outcomes of Alzheimer’s disease. Based on available evidence, we suggest that regular consumption of bioactive phytochemicals from a variety of fruits and vegetables attenuates age- and insult-related neuropathology in Alzheimer’s disease.

Keywords
Alzheimer’s Disease
Phytochemicals
Neuroprotection
Alzheimer’s Disease Prevention
Review
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