IMR Press / FBE / Volume 10 / Issue 2 / DOI: 10.2741/E818

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Inter-species functional interactome of nuclear steroid receptors (R1)

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1 First Department of Paediatrics, National and Kapodistrian University of Athens Medical School, Aghia Sophia Children’s Hospital, Athens, Greece
2 Clinical, Translational, Experimental Surgery Research Centre, Biomedical Research Foundation Academy of Athens, Athens, Greece
3 Department of Computer Science and Biomedical Informatics, University of Thessaly, Greece

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(2), 208–228; https://doi.org/10.2741/E818
Published: 1 January 2018
(This article belongs to the Special Issue Electrophysiology from bench to bedside)
Abstract

Steroids exert their actions by binding to the glucocorticoid, mineralocorticoid, androgen, estrogen and progesterone classes of receptors. Despite an exponential increase in our knowledge of steroid receptors, their interactions with other molecules, subcellular location and functions still need further elucidation. To unravel the mechanism(s) of action of the steroid hormones, as well as the function of their cognate nuclear receptors, an interaction network was created (henceforth referred to as “R1 Interactome”)- illustrating that robust interactions have been preserved in rodents, frog, zebra fish and drosophila. The generated interactome of the retrieved orthologs across species revealed: a. interactions among surface-cytosol-nuclear receptors, and/or orphan receptors and genes, and b. nuclear corepressor 1 (NCOR1) as a major “hub”, through which most steroid receptors interact. These mechanisms (i) integrate social behavior and environmental stimuli with intrinsic cellular functions, (ii) provide an explanatory mechanism of the major Public Health problem of “non-ionizing” radiation impact, surpassing the existing conflict over the “thermal”/ “non- thermal” consequences of radiation, linking all the so far proposed mechanisms, and addressing all reported effects in humans, rodents and insects, and (iii) reveal biologically or clinically important pathways and/or regulatory networks.

Keywords
translational research
ecdysteroids
ion channels
electromagnetic fields effects explanatory mechanism
endocrine axes
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