IMR Press / FBE / Volume 10 / Issue 1 / DOI: 10.2741/E813

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Age-related pathological changes in the pancreas

Show Less
1 Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(1), 137–142; https://doi.org/10.2741/E813
Published: 1 January 2018
(This article belongs to the Special Issue Cancer and aging)
Abstract

Pancreas has a complex histology and is characterized by a combination of endocrine and exocrine cells. Pancreas undergoes various pathological changes with aging characterized by increased fatty replacement, fibrosis, lymphoplasmacytic infiltration, amyloid deposition, a decreased weight as well as development of intra-epithelial neoplastic changes. These age-related alterations lead to diabetes mellitus and can predispose the individual to pancreatic ductal adenocarcinoma. In this review, we summarize age-related morphological and pathological changes of aging in pancreas.

Keywords
Age
Pancreas
Pathology
Morphology
Autopsy
Review
Share
Back to top