IMR Press / FBE / Volume 10 / Issue 1 / DOI: 10.2741/E808

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Therapeutic startegies for human papillomavirus infection and associated cancers

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1 Molecular Oncology Laboratory, Department of Zoology, University of Delhi, Delhi 110007, India
2 Division of Molecular Oncology, National Institute of Cancer Prevention and Research (ICMR), Noida, Uttar Pradesh, India

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2018, 10(1), 15–73; https://doi.org/10.2741/E808
Published: 1 January 2018
(This article belongs to the Special Issue Reproductive biomedicine: from basics to translational outcome)
Abstract

Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10-20 years for malignant progression and are preceded by well-characterized pre-cancer stages. Despite availability of window for pharmacological intervention, therapeutic that could eradicate HPV from infected lesions is currently lacking. A variety of experimental approaches have been made to address this lacuna and there has been significant progress in a number of lead molecules which are in different stages of clinical and pre-clinical development. Present review provides a brief overview of the magnitude of the problem and current status of research on promising lead molecules, formulations and therapeutic strategies that showed potential to translate to clinically-viable HPV therapeutics to counteract this reproductive health challenge.

Keywords
Cervical Cancer
Therapeutic Vaccines
RNA Interference
Genome Editing
Nutraceuticals
Herbal Derivatives
Phytochemicals
Review
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