IMR Press / FBE / Volume 1 / Issue 2 / DOI: 10.2741/E43

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

TLRs as therapeutic targets in CNS inflammation and infection
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1 Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology, Center for Drug Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA
Front. Biosci. (Elite Ed) 2009, 1(2), 476–487;
Published: 1 June 2009

Far from being an immune-inert site, the cells of the CNS, including microglia, astrocytes and neurons, express an abundance of innate immune receptors, including toll like receptors (TLR), which recognize conserved structural motifs in pathogens. These TLRs have been implicated in both infectious and non-infectious CNS pathology and appear to play important roles in both tissue surveying and repair. Therapeutics that modulate their activity are being explored for the treatment of infectious and inflammatory diseases, cancer and neurodegenerative processes. 

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