IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E9

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Development of recombinant allergens for diagnosis and therapy
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1 Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, A-5020 Salzburg, Austria
Academic Editor:Ernesto Enrique
Front. Biosci. (Elite Ed) 2009, 1(1), 77–90; https://doi.org/10.2741/E9
Published: 1 June 2009
(This article belongs to the Special Issue New insights in diagnosis and treatment of allergic diseases)
Abstract

Allergic disease represents an increasing problem in industrialized countries. However, allergy diagnosis and specific immunotherapy, the only curative approach towards the treatment of IgE-mediated disorders, are still performed like in their very beginnings more than a century ago. The use of allergen extracts of undefined contents bears the risk of anaphylactic side effects and sensitization to new allergens during immunotherapy. This review focuses on production, physicochemical, and immunological requirements, as well as on the multiple advantages of recombinant allergens and hypoallergens in comparison to conventional allergen extracts used in allergy diagnosis and therapy. Recombinant allergens offer the perspective of molecule-based allergy diagnosis and consequently safe and patient-tailored immunotherapy.

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