IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E33

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Pathogenic mechanisms of polymorphic light eruption
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1 Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036, Graz, Austria
2 Department of Dermatology, Blackburn Building, D06, University of Sydney, Sydney 2006, Australia
3 Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036, Austria
Academic Editor:Peter Wolf
Front. Biosci. (Elite Ed) 2009, 1(1), 341–354; https://doi.org/10.2741/E33
Published: 1 June 2009
(This article belongs to the Special Issue Molecular mechanisms of photo(chemo)therapy)
Abstract

Polymorphic light eruption (PLE) is a photodermatosis (i.e. "sun allergy") with a high prevalence, particularly among young women in temperate climates. It is characterized through itchy skin lesions of variable morphology, occurring in spring or early summer on sun exposed body sites. As yet the exact etiology and pathogenesis of PLE are unknown although a resistance to ultraviolet (UV)-radiation-induced immunosuppression (i.e. a physiologic phenomenon in normal healthy subjects) and a subsequent delayed type hypersensitivity (DTH) response to a UV-modified skin antigen (i.e. neo-antigen) has been suggested as a key factor in the disease. This article reviews the cellular and molecular disturbances associated with and most likely playing a role in pathogenesis of the disease.

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