IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E32

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Targeting vectors for cancer gene therapy
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1 Department of Molecular Medicine, Sapporo Medical University, Japan
2 Department of Biochemistry, School of Medicine, Fukuoka University, Japan, Nishi 17-Chome,Minami 1-Jo,Chuo-ku,Sapporo,060-8556, Japan
Front. Biosci. (Elite Ed) 2009, 1(1), 332–340;
Published: 1 June 2009

Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates for providing highly selective gene transfer to a variety of malignant tumors.

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