IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E3

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Chemokines in vasculitis
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1 Renal Unit, Royal Shrewsbury Hospital, Mytton Oak Hospital, Shrewsbury, Shropshire, United Kingdom
2 Department of Nephrology, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom
3 Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
4 Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
Front. Biosci. (Elite Ed) 2009, 1(1), 26–35;
Published: 1 June 2009

The systemic vasculitides are a group of diseases where the primary pathological process is inflammatory injury to blood vessel walls. Their clinical manifestations are highly variable and range from organ specific disease to a systemic illness that can lead, if untreated, to multi-organ failure and death. The kidneys are often involved in systemic vasculitis, particularly in small vessel vasculitis, where the glomerular capillary bed is a target for injury. This leads to a vasculitic glomerulonephritis, with focal segmental inflammation and perivascular leukocyte accumulation evolving to extracapillary accumulation of mononuclear cells (including crescents). The kinetics of leukocyte infiltration and involvement in this setting are in part dependent on the combinatorial expression of chemokines and their receptors. We discuss the evidence base for the role of the chemokine network in the renal disease of small vessel vasculitis and extend this to non-renal aspects of small vessel vasculitis other systemic vasculitides.

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