IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E28

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Immunomodulatory effects of chemokines during the early implantation window
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1 Immunopharmacology Laboratory, School of Exact and Natural Sciences, Int. Guiraldes 2160, Ciudad Universitaria, Pabellon 2 Piso 4, (C1428EHA) University of Buenos Aires, Argentina
2 Immunogenetics Laboratory, School of Medicine, Av. Cordoba 2351. University of Buenos Aires, Argentina
Academic Editor:Lukasz Wicherek
Front. Biosci. (Elite Ed) 2009, 1(1), 288–298;
Published: 1 June 2009

Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemokines---small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors--- are also required to maintain immune-privileged sites as the feto-maternal interface. Chemokines expression involves an interdependent network with the absence of a single chemokine affecting the expression of multiple other chemokines, we have chosen to focus on just two representative examples: RANTES (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte chemo-attractant protein). Here, we present updated information on their expression levels and regulation on three different levels: 1) systemic effects on maternal allogeneic response; 2) local effects on endometrial cells; and 3) during an early stage of the feto-maternal dialogue. For each of the three levels, we analyzed data from both fertile women and patients having experienced recurrent spontaneous abortions as representative of physiological and pathological situations respectively.

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