IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E22

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Different strategies for controlling DNA conformation: compaction and decompaction
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1 Physical Chemistry 1, Centre for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden
Academic Editor:Paula V. Messina
Front. Biosci. (Elite Ed) 2009, 1(1), 228–241; https://doi.org/10.2741/E22
Published: 1 June 2009
(This article belongs to the Special Issue Bioorganic and biophysical chemistry: from basics to applications)
Abstract

In the present review we summarize different strategies to induce DNA compaction and decompaction. DNA compaction is achieved using different cationic co-solutes, such as trivalent ions, surfactant, and polycations. In addition, single-chained DNA compaction can also be achieved in solvents with low dielectric constants and by confinement. The decompaction strategies depend, naturally, on the method used for the compaction and can be accomplished by, for example, heparins, cyclodextrins, non-ionic or anionic surfactants.

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