IMR Press / EJGO / Volume 9 / Issue 2 / pii/1988031

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Chemotherapy with CDDP

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1 I Gynaecological Institute, University of Bari, Italy
Eur. J. Gynaecol. Oncol. 1988, 9(2), 158–160;
Published: 10 April 1988

The Authors report the results obtained in 30 patients affected by ovarian card­noma and treated with chemotherapy using the parenteral route in 27 cases and the intraperitoneal one in 3 women. Parenteral chemotherapy following surgical staging and extensive tumour removal with the last residual tumour, consisted of a therapeutic scheme of mono- and poli-chemotherapy. The doses of cisplatin (CDDP) in mono-chemotherapy were correlated to the intensive anatomical-radiological-surgical staging. The patients treated with poli-chemotherapy underwent cycles with CDDP + alkylating agents. Moreover, 3 of the patients received low doses of cisplatin by intraperitoneal administration. In 27 cases pre- and post-therapy enzymuria was evaluated: it represents, in fact, the most reliable. laboratory test to discover an acute tubulo-toxicity and is able to reveal chronic tubular damage. Our results demonstrate that a sui table nephrologic monitoring of the patients allows a more accurate use of the cisplatin with a better cost-benefit relation.

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