IMR Press / EJGO / Volume 9 / Issue 1 / pii/1988006

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Effects of therapies of cervical cancer on the count and function of peripheral lymphocytes

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1 Department of Oncological Gynaecology, Institute of Oncology, Warsaw, Poland
Eur. J. Gynaecol. Oncol. 1988, 9(1), 20–27;
Published: 10 February 1988
Abstract

In 57 patients with stage I b cervical cancer, treated by three different methods, the total lymphocyte count, T- and B-cell counts and PHA-induced lymphocyte blast transformation were determined before and immediately after overall treatment as well as at 6-month intervals till 2.5 years after treatment. Exclusively applied radiotherapy caused, in stage I b cervical cancer patients a slight decrease in the total lymphocyte and T-cell counts, which disappeared at 3-6 months after treatment, as well as a very significant drop in the B-cell count, persisting even 2.5 years after treatment. The combined method comprising brachytherapy and surgery proved to least damage the nonspecific cell-mediated immunity, whereas the method combining brachy- and teletherapy with surgery exerted the most harmful effect on this immunity. All three therapeutic methods compared led to a significant long-term decrease in the circulating B-cell count. It seems that whereas the operative procedure did not influence the cell-mediated immunity, it intensified the brachytherapy-caused decrease in the B-cell count.

Keywords
Cell-mediated immunity
Cervical concer
Radiotherapy
Combined treatment
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