We have examined some aspects of the colpocytological preparations of 3 children affected by leucorrhea accompanied by bleed up, from which was diagnosed botryoid sarcoma. The characteristic element met in the preparations was the altered epithelial maturation in prepubral children; the presence of groups of intermediate and superficial cells, with nuclei sometimes disariatic, of anucleate scales and of discharging phenomena. In one case it was possible to observe even neoplastic and slightly differentiated cells. The Authors underline the usefulness of carrying out a colpocytological examination in the initial diagnostic stage with children affected by leucorrhea, above all if this is accompanied by bleeding.