IMR Press / EJGO / Volume 6 / Issue 2 / pii/1985026

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

HLA antigens in ovarian adenocarcinoma patients

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1 Division of Immunohemathology, National Cancer Institute, Milan, Italy
2 Division of Surgical Oncology G, National Cancer Institute, Milan, Italy
3 Division of Surgical Oncology B, National Cancer Institute, Milan, Italy
4 Division of Surgical Oncology H, National Cancer Institute, Milan, Italy
Eur. J. Gynaecol. Oncol. 1985, 6(2), 121–125;
Published: 10 June 1985
Abstract

Sixty five patients affected by ovarian carcinoma, 40 controls with benign ovarian disease were typed for HLA A, B and C antigens and compared with 132 adult female blood donors. A highly significant increase in HLA B7 antigen (p = 0,0083) and a decrease in HLA All, A28, B12 (p = 0,04; p = 0,001; p = 0.03 respectively) in patients vs controls has been noticed. The comparison among the ovarian benign disease patients, and those with ovarian carcinoma and the healthy controls showed a decrease in the HLA Al antigen frequency. Besides, the patients presented an increased and a decreased frequency of the A and O blood phenotypes respectively. These data confirm those of other Authors, and we can conclude that the neoplastic disease does not show a strong association with histocompatibility antigens.

Keywords
Ovarian cancer
HLA typing
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