IMR Press / EJGO / Volume 42 / Issue 6 / DOI: 10.31083/j.ejgo4206191
Open Access Rapid Report
The effects of PIK3CA and TP53 on prognosis in patients with Triple-negative breast cancer (TNBC): a single institution’s long-term follow-up (6 years)
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1 Faculty of Life Science and Technology, Kunming University of Science and Technoloy, 650500 Kunming, Yunnan, China
2 Department of Oncology, The Affiliated Hospital of Kunming University of Science and Technology, 650500 Kunming, Yunnan, China
3 Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, 650500 Kunming, Yunnan, China
Eur. J. Gynaecol. Oncol. 2021, 42(6), 1320–1325;
Submitted: 28 April 2021 | Revised: 3 September 2021 | Accepted: 9 September 2021 | Published: 15 December 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Objectives: This study investigated the prognostic value of PIK3CA and TP53 during a 6-year follow-up of breast cancer patients. We also analyzed the impact of other factors on progression-free survival (PFS) and patients’ overall survival (OS). Methods: The expression of estrogen receptor (ER), progesterone receptor (PR), and Ki67 in cancer tissues was detected by immunohistochemistry. For each patient, Epidermal Growth Factor Receptor 2 (HER2 was evaluated using fluorescence in situ hybridization (FISH). Sanger sequencing was used to detect hotspot mutations in PIK3CA and TP53 genes. Results: Lymph node metastasis is the most important factor affecting the patient’s prognosis (74.3% vs. 81.6%, p = 0.04). The mutation rates of PIK3CA and TP53 in Triple-negative breast cancer (TNBC) patients were significantly higher than those of other breast cancer types (29.4% vs. 3.6%, p = 0.002). In TNBC, the PFS of patients with PIK3CA and TP53 mutations is poorer than non-carriers (0% vs. 75%, p = 0.003). The OS of breast cancer patients in Yunnan Province is lower than that of regions with rapid economic development in China (78.08% vs. 90.5%). Conclusions: Our results indicate that PIK3CA and TP53 mutations are poor prognostic factors for patients with TNBC. PIK3CA and TP53 mutations could be used as a predictor for prognosis in TNBC patients.

Breast cancer
Fig. 1.
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