IMR Press / EJGO / Volume 42 / Issue 3 / DOI: 10.31083/j.ejgo.2021.03.2377
Open Access Original Research
Primary ovarian non-Hodgkin’s lymphoma: a case series and a review of literature
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1 Department of Gynecologic Oncology, Tianjin Medical University Cancer institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tian Jin; TianJin’s Clinical Research Center for Cancer, 300060 Tianjin, China
Eur. J. Gynaecol. Oncol. 2021, 42(3), 561–566;
Submitted: 12 January 2021 | Revised: 16 February 2021 | Accepted: 26 February 2021 | Published: 15 June 2021

Objectives: We report nine cases of primary ovarian non-Hodgkin’s lymphoma (PONHL). Materials and methods: From January 2000 to February 2020, we retrospectively analyzed nine patients with PONHL admitted to our hospital. Their clinicopathologic features, treatments, and outcomes were summarized. Results: This study included eight cases of DLBCLs and one case of T-cell origin. Their presentations included abdominal pain, abdominal distension, and a pelvic mass, and one had a history of B symptoms. Imaging features revealed large, solid, and homogenous adnexal lesions. Four cases had bilateral ovary involvement and one had abdominal bloody ascites. Intraoperative frozen section analysis showed that five patients had lymphoma, and four had incorrect diagnoses. All patients received surgical treatment and adjuvant chemotherapy. Three patients died of their disease, and six are alive and cancer-free. Conclusions: Preoperative diagnosis of PONHL is difficult. Correct frozen section analysis is a key determinant for guiding conservative therapy. Adjuvant R-CHOP chemotherapy might be an effective regimen.

Lymphoma and non-Hodgkin's disease
Ovarian tumors
Ovarian lymphoma
Primary ovarian lymphoma
Fig. 1.
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