IMR Press / EJGO / Volume 42 / Issue 2 / DOI: 10.31083/j.ejgo.2021.02.2291
Open Access Review
Primary diffuse large B-cell lymphoma of uterine cervix diagnosed by cytology and concurrent cervical biopsy: a case report and literatures reviews since 1980
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1 Department of Obstetrics and Gynecology, College of Medicine, Chosun University, 61453 Gwangju, Korea
2 Department of Pathology, College of Medicine, Chosun University, 61453 Gwangju, Korea
Eur. J. Gynaecol. Oncol. 2021, 42(2), 218–228;
Submitted: 30 October 2020 | Revised: 6 November 2020 | Accepted: 17 November 2020 | Published: 15 April 2021

Malignant lymphoma of the uterine cervix is rare with non-specific clinical presentation and is difficult to diagnose via cervical cytology. The current study presents a case of primary malignant lymphoma of the uterine cervix diagnosed via initial conventional smear cytology and subsequent cervical biopsy. We present a case of an 81-year-old woman with vaginal bleeding post-urination. The conventional smear cytology showed scattered large atypical lymphoid cells with necrotic debris. The concurrently biopsied specimen revealed large monotonous atypical lymphoid cells, which were immunoreactive for CD20 with high Ki-67 proliferative index, consistent with diffuse large B-cell lymphoma (DLBCL). Due to the transfer of the patient to another hospital, any other examinations associated with staging were not performed. Although rare, the likelihood of malignant lymphoma should be considered while screening for cervical cancer through cytology using Pap smear or conventional smear. Cytological screening may be useful for the early diagnosis of malignant lymphoma of the uterine cervix. Immediate and appropriate treatment can be initiated with a quick and accurate diagnosis. Herein, we report a case of primary uterine cervical DLBCL and review the literatures comprising 106 cases studies with 255 cases of primary cervical lymphoma reported since 1980 including clinical and histological characteristics through MEDLINE database.

Uterine cervix
Fig. 1.
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