IMR Press / EJGO / Volume 42 / Issue 1 / DOI: 10.31083/j.ejgo.2021.01.2119
Open Access Original Research
The European Vulvovaginal Epidemiological Survey (EVES) in Italy. Impact of vulvovaginal atrophy on the quality of life and sexual function in breast cancer survivors
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1 Research Centre for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS Policlinico San Matteo Foundation, University of Pavia, 27100 Pavia, Italy
2 University of Turin, Department of Surgical Sciences, Mauriziano Umberto I Hospital, 10128 Turin, Italy
3 2nd Unit of Obstetrics and Gynecology, Department of Biomedical and Human Oncological Science (DIMO), University of Bari, 70121 Bari, Italy
4 Shionogi srl, 00193 Rome, Italy
5 Department of Molecular and Developmental Medicine, Division of Obstetrics and Gynecology, University of Siena, 53100 Siena, Italy
6 Division of Obstetrics and Gynecology, Department of Gynecology and Obstetrics, “D. Camberlingo” Hospital, Francavilla Fontana, ASL Brindisi, 72100 Brindisi, Italy
7 Department of Women, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
8 Catholic University of Sacred Heart, Rome, 00168 Rome, Italy

§The complete list of the EVES Study investigators participating from Italian sites is as follows: A. M. Becorpi (Florence, Italy), P. Benedetti Panici (Rome, Italy), C. Benedetto (Turin, Italy), N. Biglia (Turin, Italy), M. Busacca (Milan, Italy), A. Cagnacci (Modena, Italy), A. Cianci (Catania, Italy), E. Cicinelli (Bari, Italy), F. De Seta (Trieste, Italy), C. Di Carlo (Naples, Italy), M. Gambacciani (Pisa, Italy), M. Guida (Salerno, Italy), S. Luisi (Siena, Italy), D. Marchesoni (Udine, Italy), R.E. Nappi (Pavia, Italy), A. M. Paoletti (Cagliari, Italy), S. Palacios (Madrid, Spain), A. Pellegrino (Lecco, Italy), V. Remorgida (Genoa, Italy), S. Salvatore (Milan, Italy), R. Seracchioli (Bologna, Italy), M. Stomati (Brindisi, Italy), N. Surico (Novara, Italy), P. Villa (Rome, Italy).

Eur. J. Gynaecol. Oncol. 2021, 42(1), 38–44;
Submitted: 30 April 2020 | Revised: 31 August 2020 | Accepted: 27 October 2020 | Published: 15 February 2021

The European Vulvovaginal Epidemiology Survey (EVES) sub-analysis assesses the impact of history of breast cancer (HBC) on vulvovaginal atrophy (VVA), sexual function and quality of life in a sample of postmenopausal women. Women aged 45-75 years with at least one symptom of VVA attending Italian menopause centers were included; subgroup data were described according to the absence (N = 967) or presence (N = 78) of HBC. VVA confirmed by gynecological examination and Vaginal Health Index < 15 was more prevalent in women with HBC (93.6% vs. 86.0% and 78.2% vs. 65.9%, respectively). Self-reported vaginal discharge, itching and urinary frequency were more prevalent in women without HBC compared to different HBC subgroups. Day-to-Day Impact of Vaginal Aging (DIVA) and sexual function scores were similar between women with or without HBC, but women who have completed breast cancer (BC) therapy showed lower sexual distress. Women with HBC had a higher vaginal prevalence and severity of signs of VVA, while self-reported VVA symptoms were generally less disruptive in women with HBC. These exploratory findings warrant confirmation in larger studies.

Breast cancer
Gynecological examination
Quality of life
Sexual dysfunction
Vulvovaginal atrophy
Genitourinary syndrome of menopause
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